Progress and Challenges in Basic Biology and Clinical Applications
نویسندگان
چکیده
Despite great advances of modern medical therapy, cardiac disease remains a leading cause of death worldwide. As adult cardiomyocytes have little regenerative capacity, extensive myocardial injury such as myocardial infarction leads to scar formation, cardiac remodeling, and heart failure, which are associated with high mortality. Heart transplantation is an established therapy for severe heart failure, but remains plagued with several issues, including a limited number of donor organs, chronic immunosuppressant therapy, and the subsequent development of graft vasculopathy. Thus, advances in cardiac regenerative therapy would provide an avenue to overcome these hindrances. Currently, there are several potential strategies for heart regeneration. One such approach is to generate new cardiomyocytes from endogenous cell sources in situ. This includes differentiation of resident cardiac progenitor cells into cardiomyocytes and renewal of pre-existing adult cardiomyocytes in damaged hearts. Alternatively, new cardiomyocytes could Review
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